Disease areas
Our Pipeline
Our diverse drug pipeline includes (a) infectious diseases (viral/bacterial/plasmodial) conditions, (b) geriatric neuro-degenerative diseases and (c) inflammatory conditions.
in silico
in vitro
in vivO
in vitro
(biochemical)
(whole cell)
infectious disease
Dengue Virus Disease
Complete
Ongoing
Pending
Ongoing
300MM DENV infections annually worldwide (1)
infectious disease
West Nile Virus Disease
Ongoing
Pending
Pending
Pending
3,000 infection annually in the US with 2/3rds manifesting as neuroinvasive per year (2)
infectious disease
Ebola Virus Disease
Ongoing
Pending
Pending
Pending
50% fatality rate for infections (3)
infectious disease
Resistant Staph Aureus #1
Complete
Pending
Pending
Ongoing
50% of Staph Aureus isolates are methicillin-resistant (4)
infectious disease
Resistant Staph Aureus #2
Ongoing
Pending
Pending
Pending
50% of Staph Aureus isolates are methicillin-resistant (4)
Infectious Disease
Malaria (PF)
Ongoing
Pending
Pending
Pending
200MM malaria infections annually with 400K deaths (5)
Neurological Disease
Alzheimer’s Disease
Complete
Pending
Pending
Ongoing
6MM people in the US are living with Alzheimers (6)
Neurological Disease
Parkinson's Disease
Complete
Pending
Pending
Ongoing
1MM people in the US are living with Parkinsons (7)
Orthopedic Disease
Post Traumatic Osteoarthritis
Ongoing
Pending
Pending
Pending
3.24MM people in the US are living with Post Traumatic Osteoarthritis (8)
References for Epidemiology
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Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Primers. 2016 Aug 18;2:16055. doi: 10.1038/nrdp.2016.55. PMID: 27534439.
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CDC Arbonet Surveillance for West Nile Virus (2021). https://www.cdc.gov/westnile/resources/pdfs/data/WNV-Disease-Cases-PVDs-by-State-2021-P.pdf
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WHO Ebola Factsheet 02-2021. https://www.who.int/news-room/fact-sheets/detail/ebola-virus-disease
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Lee AS, de Lencastre H, Garau J, Kluytmans J, Malhotra-Kumar S, Peschel A, Harbarth S. Methicillin-resistant Staphylococcus aureus. Nat Rev Dis Primers. 2018 May 31;4:18033. doi: 10.1038/nrdp.2018.33. PMID: 29849094.
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Phillips MA, Burrows JN, Manyando C, van Huijsduijnen RH, Van Voorhis WC, Wells TNC. Malaria. Nat Rev Dis Primers. 2017 Aug 3;3:17050. doi: 10.1038/nrdp.2017.50. PMID: 28770814.
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Alzheimer’s Foundation. 2023 Alzheimer’s Facts and Figures. https://www.alz.org/media/Documents/alzheimers-facts-and-figures.pdf
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Parkinson’s Foundation. Statistics. https://www.parkinson.org/understanding-parkinsons/statistics
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Thomas AC, Hubbard-Turner T, Wikstrom EA, Palmieri-Smith RM. Epidemiology of Posttraumatic Osteoarthritis. J Athl Train. 2017 Jun 2;52(6):491-496. doi: 10.4085/1062-6050-51.5.08. Epub 2016 May 4. PMID: 27145096; PMCID: PMC5488839.